Tholme was a Jedi Master during the last years of the Galactic Republic, who served in both the Stark Hyperspace War and the Clone Wars. After completing his Jedi training, Tholme served as Jedi Watchman of the Kiffu sector, where he came across the young Jedi hopeful Quinlan Vos. Sending him to the Jedi Temple on Coruscant, Tholme relinquished his Jedi Watchman status in favor of training Vos. Several years later, after Vos's training had been completed, a mishap occurred in which Vos lost his memory. When he had partially regained it, Tholme took it upon himself to help the wayward Jedi, and even took up Vos's former Padawan, Aayla Secura, as his own.
During the Separatist Crisis and subsequent Clone Wars, Tholme set up a spy network with Vos, hoping to glean information from the upper echelons of the Confederacy of Independent Systems. After sustaining grievous injuries from Count Dooku himself on Bakura, Tholme masterminded the plan to have Vos infiltrate Dooku's inner circle of Dark Acolytes. However, Vos turned to the dark side in earnest, and began participating in highly damaging Separatist activities against the Republic. In the meantime, Tholme participated in several Republic engagements, on worlds such as Devaron, where he was injured by the bounty hunter Aurra Sing, and Saleucami where he would turn Vos back to the light and the Republic. He was able to evade Order 66 and the subsequent Great Jedi Purge along with his lover, the Neti Jedi T'ra Saa, and took refuge on Kashyyyk, hidden from the new Imperial occupation. He eventually died, and was given a funeral pyre on Anzat.